Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 8/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | GCGR | P47871 | 4/20 | 0.44 |
| ▸ | USP8 | P40818 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 3/20 | 0.41 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592500 | 0.88 | PTGS2 (0.47) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL6261746 | 0.88 | PTGS2 (0.47) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL4592621 | 0.84 | PTGS2 (0.52) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL4593501 | 0.81 | BRAF (0.55) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL4592993 | 0.79 | MEN1 (0.57) | MAPK13MAPK12MAPK11MAPK14USP8 | |
| SCHEMBL9206412 | 0.71 | PTGS2 (0.49) | MAPK13MAPK12MAPK11MAPK14PTGS2 | |
| SCHEMBL14132548 | 0.71 | USP8 (0.59) | USP8CYP2C9MEN1KMT2AFABP3 | |
| SCHEMBL6774561 | 0.70 | MAPK14 (0.63) | MAPK13MAPK12MAPK11MAPK14GCGR | |
| SCHEMBL15070238 | 0.69 | USP8 (0.57) | USP8CYP2C9MEN1KMT2AFABP3 | |
| SCHEMBL9207835 | 0.69 | PTGS2 (0.51) | MAPK13MAPK12MAPK11MAPK14PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005030091-A2 | STENTS AND INTRA-LUMINAL PROSTHESES CONTAINING MAP KINASE INHIBITORS | SCIOS INC. (US) | 2005-04-07 | — | — | WO | disclosed |