Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 15/20 | 0.49 |
| ▸ | FNTB | P49356 | 15/20 | 0.49 |
| ▸ | PGGT1B | P53609 | 11/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | DNAJA1 | P31689 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7164493 | 0.89 | FNTA (0.54) | FNTAFNTBPGGT1BP2RX7DNAJA1 | |
| SCHEMBL6523879 | 0.86 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL7165178 | 0.81 | FNTA (0.62) | FNTAFNTBPGGT1B | |
| SCHEMBL7163140 | 0.79 | FNTA (0.46) | FNTAFNTBPGGT1BHTR1AHTR1D | |
| SCHEMBL7168685 | 0.77 | FNTA (0.47) | FNTAFNTBPGGT1BHTR1AHTR1D | |
| SCHEMBL7166206 | 0.76 | FNTA (0.54) | FNTAFNTBPGGT1B | |
| SCHEMBL7166236 | 0.75 | FNTA (0.37) | FNTAFNTBPGGT1BHTR1AHTR1D | |
| Trifluoroacetic Acid SCHEMBL7166202 | 0.74 | FNTA (0.52) | FNTAFNTBPGGT1B | |
| SCHEMBL6409378 | 0.73 | HTR1A (0.35) | FNTAFNTBPGGT1BHTR1AHTR1D | |
| SCHEMBL6430353 | 0.72 | FNTA (0.48) | FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090012-A4 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 2005-04-06 | — | — | EP | disclosed |
| US-6562823-B1 | Inhibition of farnesyl-protein transferase has been shown to block the growth of Ras-transformed cells in soft agar | MERCK & CO., INC. | 2003-05-13 | — | — | US | disclosed |
| EP-1090012-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000001702-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 2000-01-13 | — | — | WO | disclosed |