Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6526395 | 1.00 | MEN1 (0.42) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6474565 | 0.79 | MEN1 (0.50) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6482234 | 0.72 | KMT2A (0.60) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6474797 | 0.71 | KMT2A (0.59) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6475459 | 0.70 | KMT2A (0.60) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6484266 | 0.69 | MEN1 (0.46) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6474746 | 0.68 | SERPINE1 (0.47) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL6474969 | 0.68 | KMT2A (0.66) | MEN1KMT2ATDP1NPC1MAPT | |
| SCHEMBL4206812 | 0.67 | MAPT (0.72) | MEN1KMT2ANPC1MAPTMAPK1 | |
| SCHEMBL6265068 | 0.67 | MEN1 (0.38) | MEN1KMT2ATDP1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6972287-B1 | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | PFIZER INC. (US) | 2005-12-06 | — | — | US | disclosed |