Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL28430055 | 0.92 | TSHR (0.44) | TSHRALDH1A1CYP2D6CYP2C19TDP1 | |
| Methyl Alcohol SCHEMBL20524670 | 0.84 | — | — | |
| SCHEMBL20101 | 0.84 | — | — | |
| Bicarbonate SCHEMBL6526846 | 0.83 | ALDH1A1 (0.36) | TSHRALDH1A1KDM4E | |
| Isopropyl Alcohol SCHEMBL825393 | 0.81 | ALDH1A1 (0.40) | TSHRALDH1A1TDP1 | |
| Ammonia Solution, Strong SCHEMBL16412643 | 0.81 | — | — | |
| SCHEMBL29128090 | 0.81 | — | — | |
| SCHEMBL21963628 | 0.81 | — | — | |
| SCHEMBL27646232 | 0.81 | — | — | |
| Fluoride SCHEMBL27546441 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6858073-B2 | Pigmented vitreous material | CIBA SPECIALTY CHEMICALS CORPORATION (US) | 2005-02-22 | — | — | US | disclosed |
| US-20040159265-A1 | Pigmented vitreous material | BUJARD PATRICE (CH) | 2004-08-19 | — | — | US | disclosed |
| US-6737533-B2 | DISPERSION OF PIGMENT IN VITREOUS COMPOUND; CONTROLLED HEATING | CIBA SPECIALTY CHEMICALS CORPORATION | 2004-05-18 | — | — | US | disclosed |
| EP-1242327-B1 | PIGMENTED VITREOUS MATERIAL ITS PRECURSOR GLASS ITEMS COATED THEREWITH AND METHOD OF ITS PREPARATION | CIBA SC HOLDING AG (CH) | 2004-03-31 | — | — | EP | disclosed |
| US-20030140820-A1 | Pigmented vitreous material | BUJARD PATRICE (CH) | 2003-07-31 | — | — | US | disclosed |
| US-6524382-B1 | Crosslinking organic pigment or chromophore with transition metal compound | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-02-25 | — | — | US | disclosed |
| EP-1242327-A1 | PIGMENTED VITREOUS MATERIAL ITS PRECURSOR GLASS ITEMS COATED THEREWITH AND METHOD OF ITS PREPARATION | Ciba SC Holding AG (CH) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001032577-A1 | PIGMENTED VITREOUS MATERIAL ITS PRECURSOR GLASS ITEMS COATED THEREWITH AND METHOD OF ITS PREPARATION | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-05-10 | — | — | WO | disclosed |