Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17884743 | 0.89 | GPR119 (0.60) | GPR119 | |
| SCHEMBL7061216 | 0.88 | GPR119 (0.58) | GPR119KDM4E | |
| SCHEMBL21360407 | 0.86 | GPR119 (0.56) | GPR119 | |
| SCHEMBL12964697 | 0.81 | GPR119 (0.79) | GPR119KDM4E | |
| SCHEMBL19991694 | 0.77 | GPR119 (0.62) | GPR119KDM4E | |
| SCHEMBL19991692 | 0.77 | GPR119 (0.62) | GPR119KDM4E | |
| SCHEMBL19991693 | 0.77 | GPR119 (0.62) | GPR119KDM4E | |
| SCHEMBL3486839 | 0.76 | GPR119 (1.00) | GPR119KDM4E | |
| SCHEMBL6371332 | 0.75 | GPR119 (0.47) | GPR119 | |
| SCHEMBL9143759 | 0.75 | HDAC1 (0.52) | GPR119KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1608373-A2 | TIE-2 MODULATORS AND METHODS OF USE | Exelixis Inc. (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1581343-A1 | TANDEM TETRAMERISATION-POLYMERISATION OF OLEFINS | Sasol Technology (PTY) Limited (ZA) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004083235-A2 | TIE-2 MODULATORS AND METHODS OF USE | EXELIXIS INC. (US) | 2004-09-30 | — | — | WO | disclosed |
| WO-2004056480-A1 | TANDEM TETRAMERISATION-POLYMERISATION OF OLEFINS | SASOL TECHNOLOGY (PTY) LIMITED (ZA) | 2004-07-08 | — | — | WO | disclosed |