Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.63 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.63 |
| ▸ | PDE5A | O76074 | 3/20 | 0.63 |
| ▸ | PDE1A | P54750 | 3/20 | 0.63 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.63 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.63 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.55 |
| ▸ | CNR2 | P34972 | 6/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4517071 | 0.86 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL27611715 | 0.82 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4460149 | 0.80 | PDE4A (0.73) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL4461234 | 0.78 | PDE4A (0.71) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3128315 | 0.78 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3138769 | 0.78 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL185397 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL29798952 | 0.78 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL3141400 | 0.77 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DPDE5A | |
| SCHEMBL27631265 | 0.75 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1551837-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceutical Corporation (US) | 2005-07-13 | — | — | EP | claimed |
| WO-2004014911-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-02-19 | — | — | WO | claimed |