Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.79 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.56 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334612 | 0.91 | S1PR3 (0.64) | S1PR3PTPN11PTPN1PTPN6WDR5 | |
| SCHEMBL7029380 | 0.88 | S1PR3 (1.00) | S1PR3PTPN11PTPN1PTPN6ALDH1A1 | |
| SCHEMBL4125056 | 0.86 | S1PR3 (0.78) | S1PR3PTPN11PTPN1PTPN6ALDH1A1 | |
| SCHEMBL30823666 | 0.85 | S1PR3 (0.56) | S1PR3ALDH1A1WDR5LMNAKMT2A | |
| SCHEMBL4268302 | 0.85 | S1PR3 (0.56) | S1PR3ALDH1A1WDR5LMNAKMT2A | |
| SCHEMBL9388235 | 0.83 | S1PR3 (0.53) | S1PR3PTPN11ALDH1A1HPGDLMNA | |
| SCHEMBL4130038 | 0.82 | S1PR3 (0.71) | S1PR3PTPN11PTPN1PTPN6WDR5 | |
| SCHEMBL10592254 | 0.81 | PTPN11 (0.66) | S1PR3PTPN11PTPN1PTPN6ALDH1A1 | |
| SCHEMBL10426448 | 0.81 | S1PR3 (0.51) | S1PR3PTPN11ALDH1A1HPGDLMNA | |
| SCHEMBL6312300 | 0.80 | S1PR3 (0.50) | S1PR3ALDH1A1LMNACYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051655-B1 | METHODS AND APPARATUS FOR ACCELERATED ORTHOKERATOLOGY | ISTA PHARMACEUTICALS INC (US) | 2005-09-28 | — | — | EP | disclosed |
| US-20010016731-A1 | Methods and apparatus for accelerated orthokeratology | DEVORE DALE (US) | 2001-08-23 | — | — | US | disclosed |
| US-6161544-A | Methods for accelerated orthokeratology | KERATOFORM, INC. (US) | 2000-12-19 | — | — | US | disclosed |