Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 1/20 | 0.78 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | WDR5 | P61964 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4130038 | 0.96 | S1PR3 (0.71) | S1PR3PTPN11PTPN1PTPN6LMNA | |
| SCHEMBL6630953 | 0.92 | S1PR3 (0.65) | S1PR3PTPN11PTPN1PTPN6LMNA | |
| SCHEMBL7029380 | 0.88 | S1PR3 (1.00) | S1PR3PTPN11PTPN1PTPN6LMNA | |
| SCHEMBL6528344 | 0.86 | S1PR3 (0.79) | S1PR3PTPN11PTPN1PTPN6LMNA | |
| SCHEMBL2574654 | 0.85 | S1PR3 (0.57) | S1PR3LMNAWDR5ALDH1A1ADRA2A | |
| SCHEMBL4421524 | 0.84 | S1PR3 (0.56) | S1PR3PTPN11LMNAWDR5ALDH1A1 | |
| SCHEMBL6630656 | 0.83 | S1PR3 (0.55) | S1PR3LMNAWDR5MEN1NR1I2 | |
| SCHEMBL5179978 | 0.83 | S1PR3 (0.55) | S1PR3PTPN11LMNAWDR5PTGDR2 | |
| SCHEMBL6630509 | 0.82 | S1PR3 (0.54) | S1PR3PTPN11PTPN1PTPN6LMNA | |
| SCHEMBL3873094 | 0.81 | SLC6A9 (0.56) | S1PR3LMNAPTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188139-B2 | Heterocyclic-substituted phenyl methanones | HOFFMAN-LA ROCHE INC. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20090203665-A1 | HETEROCYCLIC-SUBSTITUTED PHENYL METHANONES | JOLIDON SYNESE | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203665-A1 | HETEROCYCLIC-SUBSTITUTED PHENYL METHANONES | CYP2B6, CYP2D6, CYP1A2 | S1PR3 1473/4885PTPN11 1850/4885PTPN1 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.