Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.65 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.65 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.65 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | SORD | Q00796 | 1/20 | 0.51 |
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 4/20 | 0.46 |
| ▸ | AKT2 | P31751 | 4/20 | 0.46 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2798904 | 0.86 | LMNA (0.71) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL8131399 | 0.83 | LMNA (0.97) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL11015775 | 0.83 | PTK2 (0.73) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL785334 | 0.82 | LMNA (0.70) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL8131396 | 0.82 | LMNA (0.70) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL30821993 | 0.81 | PTK2 (0.71) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL6569122 | 0.81 | PTK2 (0.71) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| Hydrochloric Acid SCHEMBL8690819 | 0.81 | LMNA (0.72) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL2795640 | 0.81 | LMNA (0.64) | LMNAHTTSMN1; SMN2HRH1HRH3 | |
| SCHEMBL2203931 | 0.80 | PTK2 (0.69) | LMNAHTTSMN1; SMN2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | ARRAY BIOPHARMA INC. | 2005-06-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130954-A1 | Serine/threonine protein kinase inhibitors; hyperproliferative disorder or inflammatory conditions; e.g. 4-(4-(2-amino-3-(p-chlorophenyl)-propionyl)-piperazin-1-yl)-quinazoline | MTOR, CDK2, CLK2 | LMNA 1761/4885HTT 4100/4885SMN1; SMN2 4501/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.