Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 4/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.52 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4702704 | 1.00 | HSD11B1 (0.67) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL5243753 | 0.92 | HSD11B1 (0.72) | HSD11B1POLBKMT2AAKR1C3AKR1C1 | |
| SCHEMBL6488610 | 0.87 | HSD11B1 (0.69) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL4701085 | 0.87 | HSD11B1 (0.66) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL4701091 | 0.87 | HSD11B1 (0.66) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL27708560 | 0.82 | HSD11B1 (0.60) | HSD11B1GAAKMT2AHTTAKR1C3 | |
| SCHEMBL4759219 | 0.81 | HSD11B1 (0.67) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL5246776 | 0.81 | POLB (0.75) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL4703556 | 0.81 | HSD11B1 (0.56) | HSD11B1POLBLMNASMN1; SMN2GAA | |
| SCHEMBL4756664 | 0.81 | HSD11B1 (0.56) | HSD11B1POLBLMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050288317-A1 | Amido compounds and their use as pharmaceuticals | INCYTE CORPORATION | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288317-A1 | Amido compounds and their use as pharmaceuticals | HSD11B1, CYP11B1, HSD11B2 | HSD11B1 1/4885POLB 2345/4885LMNA 2149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.