Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 10/20 | 0.81 |
| ▸ | MMP2 | P08253 | 3/20 | 0.60 |
| ▸ | MMP9 | P14780 | 3/20 | 0.60 |
| ▸ | MMP8 | P22894 | 3/20 | 0.60 |
| ▸ | MMP13 | P45452 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | NPC1 | O15118 | 5/20 | 0.56 |
| ▸ | RAB9A | P51151 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | CASP3 | P42574 | 1/20 | 0.56 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27202458 | 0.91 | HPSE (0.67) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6526357 | 0.90 | MMP2 (0.70) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202548 | 0.87 | HPSE (0.62) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202482 | 0.86 | HPSE (0.61) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL27202474 | 0.85 | NPC1 (0.63) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6528395 | 0.85 | HPSE (0.68) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL6530825 | 0.85 | HPSE (1.00) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL15702617 | 0.84 | MMP2 (0.64) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL15702635 | 0.84 | MMP2 (0.61) | HPSEMMP2MMP9MMP8MMP13 | |
| SCHEMBL14494924 | 0.84 | NPC1 (0.60) | HPSEMMP2MMP9MMP8MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |