Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 5/20 | 0.65 |
| ▸ | HTR1D | P28221 | 4/20 | 0.65 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | SIRT1 | Q96EB6 | 8/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.46 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.46 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529421 | 1.00 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| Oxalic Acid SCHEMBL7543349 | 0.92 | HTR1B (0.66) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL15281767 | 0.84 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL14624295 | 0.84 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL24408213 | 0.82 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL7409510 | 0.82 | SIRT1 (0.55) | HTR1BHTR1DSIRT1SIRT2SIRT3 | |
| SCHEMBL23657201 | 0.82 | KMT2A (0.64) | HTR1BHTR1DSIRT1BAZ2BKMT2A | |
| SCHEMBL9336395 | 0.82 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL24408397 | 0.82 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6SIRT1 | |
| SCHEMBL9334201 | 0.82 | HTR1B (0.69) | HTR1BHTR1DNR2E1HTR6EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | claimed |
| EP-0591280-A1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000086-A1 | USE OF TETRAHYDROCARBAZONE DERIVATIVES AS 5HT1 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | claimed |
| WO-2005033099-A2 | NOVEL DIPEPTIDYL PEPTIDASE IV INHIBITORS; PROCESSES FOR THEIR PREPARATION AND COMPOSITIONS THEREOF | GLENMARK PHARMACEUTICALS LTD. (US) | 2005-04-14 | — | — | WO | disclosed |