Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.69 |
| ▸ | HTR1D | P28221 | 3/20 | 0.69 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.64 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RB1 | P06400 | 4/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.47 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL7540449 | 0.92 | HTR1B (0.66) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL15281767 | 0.84 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL14624295 | 0.84 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL11576749 | 0.84 | KMT2A (0.65) | HTR1BHTR1DL3MBTL1RB1ACHE | |
| SCHEMBL24408397 | 0.82 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL833781 | 0.82 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL6529419 | 0.82 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL24408213 | 0.82 | HTR1B (0.67) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL6529421 | 0.82 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR | |
| SCHEMBL9336395 | 0.82 | HTR1B (0.65) | HTR1BHTR1DNR2E1HTR6EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603432-A1 | Tetrahydrocarbazole derivatives for the manufacture of a medicament for the treatment of a disease where a 5-HT1-like agonist is indicated | SMITHKLINE BEECHAM PLC (GB) | 1994-06-29 | — | — | EP | claimed |
| EP-0591280-A1 | USE OF TETRAHYDROCARBAZOLE DERIVATIVES AS 5HT1-RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1994-04-13 | — | — | EP | claimed |
| WO-1993000086-A1 | USE OF TETRAHYDROCARBAZONE DERIVATIVES AS 5HT1 RECEPTOR AGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1993-01-07 | — | — | WO | claimed |