Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 11/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | PARP1 | P09874 | 4/20 | 0.55 |
| ▸ | DHODH | Q02127 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.50 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6527816 | 0.93 | HPSE (1.00) | HPSEKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL6529350 | 0.83 | HPSE (1.00) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL25674602 | 0.80 | HPSE (0.78) | HPSEKDM4ENPC1ALDH1A1HPGD | |
| SCHEMBL20597842 | 0.80 | MGAM (0.68) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL29625822 | 0.80 | HPSE (0.65) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL28027630 | 0.80 | HPSE (0.65) | HPSEKDM4ENPC1ALDH1A1TP53 | |
| SCHEMBL6530552 | 0.78 | HPSE (0.64) | HPSEALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL1170818 | 0.78 | CBFB (0.69) | HPSEALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL21705586 | 0.76 | HPSE (0.62) | HPSEALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL31027953 | 0.76 | HPSE (0.62) | HPSEALDH1A1TP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |