Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPSE | Q9Y251 | 2/20 | 0.64 |
| ▸ | PARP1 | P09874 | 16/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | TNKS | O95271 | 1/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | CBFB | Q13951 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511295 | 0.84 | MGAM (0.63) | HPSEPARP1ALOX15PLA2G2APTGS2 | |
| SCHEMBL6529477 | 0.78 | HPSE (1.00) | HPSEPARP1ALOX15PLA2G2APTGS2 | |
| SCHEMBL20597842 | 0.78 | MGAM (0.68) | HPSEPARP1ALOX15PLA2G2APTGS2 | |
| SCHEMBL28027630 | 0.78 | HPSE (0.65) | HPSEPARP1ALOX15TNKSTNKS2 | |
| SCHEMBL29625822 | 0.78 | HPSE (0.65) | HPSEPARP1ALOX15TNKSTNKS2 | |
| SCHEMBL1170818 | 0.76 | CBFB (0.69) | HPSEPARP1ALOX15TNKSTNKS2 | |
| SCHEMBL6508734 | 0.76 | KDM4E (0.59) | HPSEALDH1A1TP53HPGDSMN1; SMN2 | |
| SCHEMBL21705586 | 0.75 | HPSE (0.62) | HPSEPARP1ALOX15PLA2G2APTGS2 | |
| SCHEMBL31027953 | 0.75 | HPSE (0.62) | HPSEPARP1ALOX15PLA2G2APTGS2 | |
| SCHEMBL28425038 | 0.74 | TNKS (0.72) | HPSEPARP1ALOX15TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |