Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.56 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.56 |
| ▸ | DRD1 | P21728 | 2/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.56 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.56 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990358 | 0.90 | TBXA2R (0.68) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL3176152 | 0.89 | TBXA2R (0.61) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL31473037 | 0.87 | TBXA2R (0.75) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL4986252 | 0.87 | TBXA2R (0.75) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL3185862 | 0.87 | TBXA2R (0.75) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL8296573 | 0.86 | HTR1A (0.73) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL14263736 | 0.85 | TBXA2R (0.61) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL8294974 | 0.85 | TBXA2R (0.57) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL8451964 | 0.83 | TBXA2R (0.52) | HTR1AADRA2ACHRM1DRD1TBXA2R | |
| SCHEMBL8525144 | 0.83 | TBXA2R (0.61) | HTR1AADRA2ACHRM1DRD1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005080354-A1 | 1,2,4-TRIAZINES DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN HUMAN THERAPEUTICS | PIERRE FABRE MEDICAMENT (FR) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005016885-A2 | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE | ARTESIAN THERAPEUTICS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |
| WO-2005016885-A2 | COMPOUNDS WITH COMBINED CALCIUM CHANNEL BLOCKER AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITIES FOR TREATMENT OF HEART DISEASE | ARTESIAN THERAPEUTICS, INC. (US) | 2005-02-24 | — | — | WO | disclosed |