Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 8/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 5/20 | 0.35 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528390 | 0.92 | KCNH2 (0.56) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL6527610 | 0.85 | KCNH2 (0.59) | KCNH2TOP2ATOP2BKDM4EALDH1A1 | |
| SCHEMBL6509902 | 0.81 | KCNH2 (0.52) | KCNH2CYP3A4TOP2ATOP2BKDM4E | |
| SCHEMBL6528949 | 0.80 | KCNH2 (0.57) | KCNH2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL5465211 | 0.77 | — | — | |
| SCHEMBL6528463 | 0.76 | KCNH2 (0.65) | KCNH2CYP3A4TOP2ATOP2BKDM4E | |
| SCHEMBL6371961 | 0.76 | KCNH2 (0.48) | KCNH2CYP3A4TOP2ATOP2BKDM4E | |
| SCHEMBL6377865 | 0.76 | KCNH2 (0.52) | KCNH2CYP3A4TOP2ATOP2BKDM4E | |
| SCHEMBL6530656 | 0.76 | KCNH2 (0.54) | KCNH2CYP3A4TOP2ATOP2BKDM4E | |
| SCHEMBL6530621 | 0.75 | KCNH2 (0.52) | KCNH2CYP3A4TOP2ATOP2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049602-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049602-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | disclosed |