Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 9/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | TOP2A | P11388 | 2/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6510775 | 0.90 | KCNH2 (0.54) | KCNH2GSK3BPOLBCACNA1FMAPK1 | |
| SCHEMBL6530323 | 0.86 | KCNH2 (0.46) | KCNH2HRH3GSK3BPOLBCACNA1F | |
| SCHEMBL6530386 | 0.85 | KCNH2 (0.56) | KCNH2HRH3POLBTOP2ATOP2B | |
| SCHEMBL6529152 | 0.84 | KCNH2 (0.51) | KCNH2HRH3GSK3BPOLBCACNA1F | |
| SCHEMBL6529274 | 0.81 | KCNH2 (0.74) | KCNH2POLBTOP2ATOP2BALDH1A1 | |
| SCHEMBL6532564 | 0.79 | KCNH2 (0.60) | KCNH2GSK3BPOLBCACNA1FMAPK1 | |
| SCHEMBL6528801 | 0.78 | KCNH2 (0.72) | KCNH2GSK3BPOLBALDH1A1OPRM1 | |
| SCHEMBL5463190 | 0.78 | KCNH2 (0.33) | KCNH2 | |
| SCHEMBL5459698 | 0.77 | KCNH2 (0.32) | KCNH2 | |
| SCHEMBL6499864 | 0.76 | KCNH2 (0.53) | KCNH2GSK3BPOLBCACNA1FMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005049602-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005049602-A1 | QUINOLONE ANTIBACTERIAL AGENTS | WARNER-LAMBERT COMPANY LLC (US) | 2005-06-02 | — | — | WO | disclosed |