Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 8/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.47 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6506232 | 0.99 | MAPK1 (0.48) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6507196 | 0.90 | MAPK1 (0.49) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6509035 | 0.85 | MAPK1 (0.48) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6507207 | 0.84 | MAPK1 (0.47) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6509261 | 0.84 | MAPK1 (0.49) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6507091 | 0.80 | CHEK1 (0.47) | MAPK1GFERIKBKBMAPK10MEN1 | |
| SCHEMBL6530184 | 0.79 | CHEK1 (0.48) | MAPK1GFERIKBKBCHEK1 | |
| SCHEMBL6507350 | 0.79 | MAPK1 (0.43) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6510436 | 0.79 | MAPK1 (0.43) | MAPK1GFERIKBKBMAPK10JAK2 | |
| SCHEMBL6506520 | 0.79 | MAPT (0.44) | MAPK1GFERIKBKBMAPK10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005105777-A1 | SUBSTITUTED THIOPHENE AMIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-11-10 | — | — | WO | disclosed |
| WO-2005051381-A1 | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) | BIOVITRUM AB (SE) | 2005-06-09 | — | — | WO | disclosed |