Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 15/20 | 0.42 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.39 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.39 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6530624 | 0.91 | IMPDH2 (0.41) | IMPDH2AAK1IMPDH1 | |
| Trifluoroacetic Acid SCHEMBL6528447 | 0.90 | IMPDH2 (0.45) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL6528450 | 0.84 | IMPDH2 (0.44) | IMPDH2AAK1IMPDH1 | |
| Trifluoroacetic Acid SCHEMBL6530330 | 0.82 | IMPDH2 (0.41) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL5056838 | 0.81 | IMPDH2 (0.46) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL6533966 | 0.81 | IMPDH2 (0.51) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL6531402 | 0.80 | IMPDH2 (0.46) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL5134743 | 0.80 | IMPDH2 (0.44) | IMPDH2AAK1IMPDH1 | |
| SCHEMBL16508273 | 0.79 | IMPDH2 (0.44) | IMPDH2AAK1IMPDH1F11KLKB1 | |
| SCHEMBL6532503 | 0.79 | IMPDH2 (0.44) | IMPDH2AAK1IMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |