Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 14/20 | 0.70 |
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | EGFR | P00533 | 3/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6528725 | 0.93 | SRC (0.60) | SRCKDREGFR | |
| SCHEMBL3677246 | 0.82 | SRC (1.00) | SRCKDREGFR | |
| SCHEMBL4388812 | 0.76 | SRC (0.61) | SRCKDREGFRKDM1A | |
| SCHEMBL3674907 | 0.75 | SRC (0.86) | SRCKDREGFR | |
| SCHEMBL4376854 | 0.75 | SRC (0.65) | SRCKDREGFRKDM1AATM | |
| SCHEMBL3730315 | 0.74 | SRC (0.85) | SRCKDREGFR | |
| SCHEMBL4384520 | 0.74 | SRC (0.60) | SRCKDREGFRKDM1A | |
| SCHEMBL3680459 | 0.74 | SRC (0.85) | SRCKDREGFR | |
| SCHEMBL4379769 | 0.74 | SRC (0.60) | SRCKDREGFRKDM1A | |
| Hydrochloric Acid SCHEMBL4379495 | 0.74 | SRC (0.74) | SRCKDREGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | Astrazeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043472-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |