Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.60 |
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.49 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.49 |
| ▸ | KDR | P35968 | 6/20 | 0.47 |
| ▸ | EGFR | P00533 | 4/20 | 0.47 |
| ▸ | KIT | P10721 | 3/20 | 0.47 |
| ▸ | FLT4 | P35916 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.47 |
| ▸ | TEK | Q02763 | 2/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 1/20 | 0.47 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | STK10 | O94804 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531933 | 0.93 | SRC (0.70) | SRCKDREGFR | |
| SCHEMBL3674907 | 0.82 | SRC (0.86) | SRCKDREGFRFLT4TEK | |
| SCHEMBL3680459 | 0.81 | SRC (0.85) | SRCKDREGFRFLT4TEK | |
| SCHEMBL3730315 | 0.76 | SRC (0.85) | SRCKDREGFRFLT4PDGFRB | |
| SCHEMBL4378567 | 0.75 | ABCB11 (0.64) | SRCEHMT2EHMT1TLR9TLR7 | |
| SCHEMBL3677246 | 0.75 | SRC (1.00) | SRCKDREGFRFLT4FGFR1 | |
| SCHEMBL4380404 | 0.74 | FLT4 (0.63) | SRCKDREGFRKITFLT4 | |
| SCHEMBL3671373 | 0.74 | SRC (0.80) | SRCKDREGFRFLT4FGFR1 | |
| SCHEMBL4383740 | 0.73 | RET (0.75) | SRCKDREGFRKITFLT4 | |
| SCHEMBL4381975 | 0.73 | ABCB11 (0.62) | SRCKDREGFRKITFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562612-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | Astrazeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043472-A1 | COMBINATION PRODUCT OF INHIBITOR OF THE SRC FAMILY OF NON-RECEPTOR TYROSINE KINASES AND GEMCITABINE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |