Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532894 | 0.80 | KDM4E (0.37) | BMP1 | |
| SCHEMBL6532274 | 0.74 | USP7 (0.44) | USP7CCR5POLB | |
| SCHEMBL6332424 | 0.74 | USP7 (0.46) | USP7CCR5POLB | |
| SCHEMBL4713995 | 0.73 | HCRTR1 (0.43) | USP7CCR5IDH1HCRTR1HCRTR2 | |
| Oxalic Acid SCHEMBL9702943 | 0.71 | USP7 (0.49) | USP7HCRTR1HCRTR2 | |
| Oxalic Acid SCHEMBL9702934 | 0.71 | USP7 (0.49) | USP7HCRTR1HCRTR2 | |
| SCHEMBL13827635 | 0.70 | POLB (0.40) | IDH1HCRTR1HCRTR2POLB | |
| SCHEMBL469197 | 0.70 | POLB (0.40) | IDH1HCRTR1HCRTR2POLB | |
| SCHEMBL13246658 | 0.68 | USP7 (0.54) | USP7CCR5 | |
| SCHEMBL22930811 | 0.67 | POLB (0.39) | IDH1HCRTR1HCRTR2POLBCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |