Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | CPT1A | P50416 | 3/20 | 0.39 |
| ▸ | CPT2 | P23786 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SPR | P35270 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL9702943 | 1.00 | USP7 (0.49) | USP7HSD11B1HCRTR1HCRTR2SMO | |
| SCHEMBL19450546 | 0.91 | USP7 (0.52) | USP7HSD11B1SMN1; SMN2CNR1CNR2 | |
| Oxalic Acid SCHEMBL10419843 | 0.85 | HSD11B1 (0.50) | HSD11B1HCRTR1HCRTR2ALDH1A1SMN1; SMN2 | |
| Oxalic Acid SCHEMBL10419846 | 0.84 | HSD11B1 (0.50) | HSD11B1SMO | |
| Oxalic Acid SCHEMBL10419848 | 0.84 | HSD11B1 (0.50) | HSD11B1SMO | |
| SCHEMBL2023091 | 0.82 | TUBB4A (0.42) | HSD11B1HCRTR1HCRTR2SMOCPT1A | |
| SCHEMBL18711263 | 0.81 | SMO (0.45) | HSD11B1HCRTR1HCRTR2SMOSMN1; SMN2 | |
| Oxalic Acid SCHEMBL9702698 | 0.78 | CHRM2 (0.51) | SMO | |
| Oxalic Acid SCHEMBL9702684 | 0.78 | CHRM2 (0.51) | SMO | |
| SCHEMBL18702095 | 0.77 | HSD11B1 (0.41) | HSD11B1HCRTR1HCRTR2SMN1; SMN2SPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0259621-B1 | PIPERIDINE COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1992-11-25 | — | — | EP | disclosed |
| US-4933353-A | ALZHEIMER*S DISEASE | A/S FERROSAN (DE) | 1990-06-12 | — | — | US | disclosed |
| US-4837241-A | TREATMENT OF ALZEHEIMER*S DISEASE | A/S FERROSAN (DK) | 1989-06-06 | — | — | US | disclosed |
| EP-0259621-A2 | Piperidine compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1988-03-16 | — | — | EP | disclosed |