Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.54 |
| ▸ | RAB9A | P51151 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.54 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 3/20 | 0.51 |
| ▸ | MMP9 | P14780 | 3/20 | 0.51 |
| ▸ | MMP8 | P22894 | 3/20 | 0.51 |
| ▸ | MMP13 | P45452 | 2/20 | 0.51 |
| ▸ | COMT | P21964 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 4/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6532479 | 0.80 | NPC1 (0.61) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL1767523 | 0.79 | MMP2 (0.67) | NPC1RAB9AKDM4EALDH1A1MMP2 | |
| SCHEMBL30726447 | 0.77 | MMP2 (0.62) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL31592975 | 0.76 | MMP2 (0.64) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL11460149 | 0.76 | NPC1 (0.61) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL31592970 | 0.75 | KDM4E (0.61) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL31592944 | 0.74 | KDM4E (0.57) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL13151491 | 0.74 | MAPK10 (0.62) | NPC1RAB9AMAPTATMEGFR | |
| SCHEMBL31592951 | 0.74 | MMP2 (0.55) | NPC1RAB9AGAAKDM4EALDH1A1 | |
| SCHEMBL27040119 | 0.74 | MMP2 (0.55) | NPC1RAB9AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042495-A1 | (BENZIMIDAZOL-2-YL)-PHENYL-PHENYL-UREA COMPOUNDS AND METHODS FOR INHIBITING HEPARANASE ACTIVITY | IMCLONE SYSTEMS INCORPORATED (US) | 2005-05-12 | — | — | WO | disclosed |