Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6326515 | 0.77 | TSHR (0.48) | FFAR1TSHRLMNASMN1; SMN2 | |
| SCHEMBL6472559 | 0.66 | ACACB (0.60) | FFAR1S1PR1LMNA | |
| SCHEMBL6334787 | 0.62 | ZAP70 (0.32) | HCAR2FFAR1 | |
| SCHEMBL563100 | 0.60 | PPARD (0.54) | HCAR2FFAR1DPP4DPP7TSHR | |
| SCHEMBL6532275 | 0.60 | USP7 (0.44) | — | |
| SCHEMBL27745689 | 0.60 | FFAR1 (0.59) | FFAR1S1PR1DPP4DPP7TSHR | |
| SCHEMBL6532894 | 0.58 | KDM4E (0.37) | DPP4DPP7 | |
| SCHEMBL1677568 | 0.57 | FFAR1 (0.54) | FFAR1TSHR | |
| SCHEMBL1827571 | 0.56 | CTSA (0.45) | — | |
| SCHEMBL32680319 | 0.55 | DPP4 (0.37) | FFAR1DPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1423120-A4 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORP (US) | 2005-12-28 | — | — | EP | disclosed |
| EP-1423120-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2004-06-02 | — | — | EP | disclosed |
| WO-2003015785-A1 | 2H-PHTHALAZIN-1-ONES AND METHODS FOR USE THEREOF | ICOS CORPORATION (US) | 2003-02-27 | — | — | WO | disclosed |