SCHEMBL6533395

SCHEMBL6533395

COC(=S)NCc1cn(-c2cc(F)c(N3CCN(C(=O)CNC(N)=O)CC3)c(F)c2)nn1

nearest known ligand 0.36

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.36
CA2 P00918 3/20 0.36
CA9 Q16790 3/20 0.36
CA12 O43570 2/20 0.36
NOTUM Q6P988 1/20 0.35
NPC1 O15118 2/20 0.35
MIF P14174 5/20 0.35
RAB9A P51151 1/20 0.33
GAA P10253 1/20 0.33
CA4 P22748 1/20 0.33
CA7 P43166 1/20 0.33
KDM1A O60341 1/20 0.33
APP P05067 1/20 0.32
ALK Q9UM73 1/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6528709 0.92 NOTUM (0.42) CA1CA2CA9CA12NOTUM
SCHEMBL6529468 0.89 CA1 (0.46) CA1CA2CA9CA12NOTUM
SCHEMBL6528525 0.89 NOTUM (0.36) CA1CA2CA9CA12NOTUM
SCHEMBL6531446 0.88 NOTUM (0.37) CA1CA2CA9CA12NOTUM
SCHEMBL6529698 0.87 MIF (0.38) CA1CA2CA9CA12NOTUM
SCHEMBL6530492 0.87 ALDH1A1 (0.37) CA1CA2CA9CA12NOTUM
SCHEMBL6527807 0.86 NOTUM (0.38) CA1CA2CA9CA12NOTUM
SCHEMBL6528475 0.86 NOTUM (0.34) CA1CA2CA9CA12NOTUM
SCHEMBL6528430 0.85 NOTUM (0.37) CA1CA2CA9CA12NOTUM
SCHEMBL6529616 0.85 NOTUM (0.35) CA1CA2CA9CA12NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082892-A2 TRIAZOLE COMPOUNDS AS ANTIBACTERIAL AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM DR. REDDY'S LABORATORIES LTD. (IN) 2005-09-09 WO disclosed