Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143484 | 0.73 | MEN1 (0.30) | MAPTMEN1KMT2A | |
| SCHEMBL7144459 | 0.72 | BCHE (0.33) | KDM4EMEN1KMT2A | |
| SCHEMBL9595697 | 0.71 | ALDH1A1 (0.39) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL5333422 | 0.70 | ALDH1A1 (0.35) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL7140452 | 0.69 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL7140456 | 0.69 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL7146583 | 0.69 | — | — | |
| SCHEMBL7146587 | 0.69 | — | — | |
| SCHEMBL6488206 | 0.67 | — | — | |
| SCHEMBL28820141 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6894048-B2 | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. (US) | 2005-05-17 | — | — | US | disclosed |
| US-20040058928-A1 | Sulfur Containing dihydrophthalazine antagonists of excitatory amino acid receptors | ANNOVIS, INC. | 2004-03-25 | — | — | US | disclosed |
| US-6703390-B2 | SEDATIVES, NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | TRANSGENOMIC, INC. | 2004-03-09 | — | — | US | disclosed |
| EP-1274689-A2 | SULFUR CONTAINING DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | Annovis, Inc. (US) | 2003-01-15 | — | — | EP | disclosed |
| US-20020006925-A1 | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors | TRANSGENOMIC, INC. | 2002-01-17 | — | — | US | disclosed |
| WO-2001079181-A2 | SULFUR CONTAINING DIHYDROPHTHALAZINE ANTAGONISTS OF EXCITATORY AMINO ACID RECEPTORS | ANNOVIS, INC. (US) | 2001-10-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020006925-A1 | Sulfur containing dihydrophthalazine antagonists of excitatory amino acid receptors | GRIN2A, GRIK5, SLC1A2 | ALDH1A1 1471/4885KDM4E 3833/4885MAPT 1426/4885 |
| US-20040058928-A1 | Sulfur Containing dihydrophthalazine antagonists of excitatory amino acid receptors | GRIN2A, GRIK5, SLC1A2 | ALDH1A1 1471/4885KDM4E 3833/4885MAPT 1426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.