Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.31 |
| ▸ | RARA | P10276 | 1/20 | 0.31 |
| ▸ | RARB | P10826 | 1/20 | 0.31 |
| ▸ | RARG | P13631 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | RXRG | P48443 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6511649 | 0.91 | RXRA (0.31) | RXRA | |
| SCHEMBL6533640 | 0.82 | RXRA (0.31) | RXRARARARARBRARGRXRB | |
| SCHEMBL6086567 | 0.80 | RXRA (0.31) | RXRA | |
| SCHEMBL6363628 | 0.79 | RXRA (0.40) | RXRARARARARBRARGRXRB | |
| SCHEMBL6511296 | 0.78 | — | — | |
| SCHEMBL6275325 | 0.78 | RXRA (0.37) | RXRARARARARBRARGRXRB | |
| SCHEMBL6275330 | 0.78 | RXRA (0.37) | RXRARARARARBRARGRXRB | |
| SCHEMBL727912 | 0.76 | RXRA (0.46) | RXRARARARARBRARGRXRB | |
| SCHEMBL6086974 | 0.74 | PTPN1 (0.35) | RXRA | |
| SCHEMBL6509614 | 0.73 | PPARG (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005042509-A1 | 7-`(7-ALKOXY)-CHROM-3-EN-6-YL!-HEPTATRIENOIC ACID AND 7-`(3ALKOXY)-5,6-DIHYDRONAPHTHALEN-2-YL!-HEPTATRIENOIC ACID DERIVATIVES MODULATORS | ALLERGAN, INC. (US) | 2005-05-12 | — | — | WO | disclosed |