Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 3/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28162811 | 0.75 | CYP2D6 (0.36) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28761087 | 0.74 | — | — | |
| SCHEMBL18584972 | 0.68 | — | — | |
| SCHEMBL881080 | 0.67 | SLC6A2 (0.40) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11671291 | 0.67 | CYP2D6 (0.32) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7664176 | 0.66 | CA1 (0.36) | — | |
| SCHEMBL880998 | 0.66 | SLC6A2 (0.39) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8654009 | 0.66 | SLC6A2 (0.39) | CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8191644 | 0.65 | PPARD (0.39) | — | |
| SCHEMBL28001960 | 0.65 | BRPF1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575966-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004058782-A1 | THERAPEUTIC QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2004-07-15 | — | — | WO | disclosed |