Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.63 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | ACACA | Q13085 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | ESRRB | O95718 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | ESRRA | P11474 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.51 |
| ▸ | TACR3 | P29371 | 3/20 | 0.51 |
| ▸ | ACP1 | P24666 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496204 | 0.92 | KDM4E (0.65) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL29636809 | 0.92 | KDM4E (0.65) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL4909833 | 0.91 | KDM4E (0.59) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL374734 | 0.90 | KDM4E (0.72) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL6534318 | 0.85 | MAPT (0.71) | KDM4ESMN1; SMN2AURKAAURKBALDH1A1 | |
| SCHEMBL29636789 | 0.85 | MAPT (0.71) | KDM4ESMN1; SMN2AURKAAURKBALDH1A1 | |
| SCHEMBL28350370 | 0.84 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL30064616 | 0.84 | KDM4E (0.75) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL1289553 | 0.84 | ACP1 (0.56) | KDM4ESMN1; SMN2MEN1KMT2AAURKA | |
| SCHEMBL13757621 | 0.83 | SMN1; SMN2 (1.00) | KDM4ESMN1; SMN2MEN1KMT2AAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1088818-B1 | Quinolin-4-yl derivatives | HOFFMANN LA ROCHE (CH) | 2004-11-03 | — | — | EP | disclosed |
| US-6440995-B1 | NMDA-RECEPTOR SUBTYPE SELECTIVE BLOCKERS | HOFFMAN-LA ROCHE INC. | 2002-08-27 | — | — | US | disclosed |
| EP-1088818-A1 | Quinolin-4-yl derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-04-04 | — | — | EP | disclosed |
| US-5506235-A | Quinoline derivatives as immunostimulants | PFIZER INC. (US) | 1996-04-09 | — | — | US | disclosed |
| EP-0597003-A1 | QUINOLINE DERIVATIVES AS IMMUNOSTIMULANTS | PFIZER INC. (US) | 1994-05-18 | — | — | EP | disclosed |
| WO-1993003030-A1 | QUINOLINE DERIVATIVES AS IMMUNOSTIMULANTS | PFIZER INC. (US) | 1993-02-18 | — | — | WO | disclosed |