Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | PLA2G2A | P14555 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | ESRRB | O95718 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | ESRRA | P11474 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ACACA | Q13085 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | ACP1 | P24666 | 3/20 | 0.51 |
| ▸ | DHODH | Q02127 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4496204 | 1.00 | KDM4E (0.65) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL6534209 | 0.92 | KDM4E (0.71) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL1289553 | 0.88 | ACP1 (0.56) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL6534170 | 0.88 | KDM4E (0.58) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL4909833 | 0.87 | KDM4E (0.59) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL29636789 | 0.86 | MAPT (0.71) | KDM4EAURKAAURKBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6534318 | 0.86 | MAPT (0.71) | KDM4EAURKAAURKBSMN1; SMN2ALDH1A1 | |
| SCHEMBL23015316 | 0.85 | KDM4E (0.61) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL29636817 | 0.85 | KDM4E (0.61) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 | |
| SCHEMBL4475462 | 0.84 | KDM4E (0.53) | KDM4EPLA2G2AAURKAAURKBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4017492-A1 | MOLECULES THAT BIND TO TDP-43 FOR THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS AND RELATED DISORDERS | Biohaven Therapeutics Ltd. (US) | 2022-06-29 | — | — | EP | disclosed |
| CN-114667145-A | Molecules that bind to TDP-43 for the treatment of amyotrophic lateral sclerosis and related disorders | 拜尔哈文制药股份有限公司 | 2022-06-24 | — | — | CN | disclosed |