Leucine

Leucine

SCHEMBL6534740

CC(C)C[C@H](N)C(=O)O.NCC(=O)OC(=O)CN.O=C(O)[C@H]1NCCC1O

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 1/20 0.43
SLC1A2 P43004 4/20 0.36
SLC1A3 P43003 3/20 0.36
ARG1 P05089 1/20 0.33
SLC1A1 P43005 3/20 0.32
GRIK1 P39086 2/20 0.32
GRIK2 Q13002 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucine SCHEMBL4612401 0.90 SLC7A5 (0.36) SLC7A5SLC1A2SLC1A3
Leucine SCHEMBL6370664 0.85 SLC7A5 (0.42) SLC7A5SLC1A2SLC1A3ARG1SLC1A1
SCHEMBL6534977 0.81 SLC1A2 (0.33) SLC1A2ARG1
SCHEMBL2888794 0.79 SLC1A2 (0.41) SLC7A5SLC1A2SLC1A3ARG1SLC1A1
Valine SCHEMBL4399434 0.78 SLC7A5 (0.33) SLC7A5SLC1A2
SCHEMBL3091834 0.78 SLC1A2 (0.40) SLC1A2ARG1
Aspartic Acid SCHEMBL8016849 0.76 GRIK1 (0.42) SLC1A2ARG1GRIK1GRIK2
Aspartic Acid SCHEMBL135826 0.76 GRIK1 (0.38) SLC1A2ARG1GRIK1GRIK2
Alanine SCHEMBL7049985 0.76 SLC1A2 (0.46) SLC1A2ARG1
Leucine SCHEMBL5666832 0.76 SLC7A5 (0.38) SLC7A5SLC1A2SLC1A3ARG1SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1064010-A4 PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME CONNECTIVE TISSUE IMAGINEERING (US) 2004-10-06 EP claimed
EP-1064010-A1 PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME Mrs, Llc (US) 2001-01-03 EP claimed
WO-1999045941-A1 PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME MRS, LLC (US) 1999-09-16 WO claimed