SCHEMBL6534959

SCHEMBL6534959

CCCC(CSCC(CCC)c1ccccc1O)c1ccccc1O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
GABRA1 P14867 1/20 0.44
GABRB2 P47870 1/20 0.44
POLB P06746 3/20 0.37
ESR1 P03372 1/20 0.35
ESR2 Q92731 1/20 0.35
NQO1 P15559 1/20 0.33
HTR1A P08908 1/20 0.32
NOS3 P29474 2/20 0.31
NOS1 P29475 2/20 0.31
NOS2 P35228 2/20 0.31
LMNA P02545 2/20 0.31
ALOX15 P16050 2/20 0.31
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
CA12 O43570 1/20 0.31
GMNN O75496 1/20 0.31
ALDH1A1 P00352 1/20 0.31
EGFR P00533 1/20 0.31
CA2 P00918 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6534892 0.90 TSHR (0.46) TSHRGABRA1GABRB2POLBLMNA
SCHEMBL6534841 0.88 TSHR (0.44) TSHRGABRA1GABRB2POLBLMNA
SCHEMBL6535285 0.87 TSHR (0.43) TSHRGABRA1GABRB2ALDH1A1MAPT
SCHEMBL6535240 0.87 TSHR (0.43) TSHRGABRA1GABRB2ALDH1A1MAPT
SCHEMBL983828 0.87 TSHR (0.57) TSHRGABRA1GABRB2POLBESR1
SCHEMBL982520 0.83 TSHR (0.59) TSHRGABRA1GABRB2POLBESR1
SCHEMBL26696609 0.81 TSHR (0.52) TSHRGABRA1GABRB2POLBESR1
SCHEMBL30628000 0.80 TSHR (0.50) TSHRGABRA1GABRB2POLBESR1
SCHEMBL177521 0.80 TSHR (0.50) TSHRGABRA1GABRB2POLBESR1
SCHEMBL9507974 0.80 TSHR (0.40) TSHRGABRA1GABRB2ESR1ESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0958275-A4 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 UNIV VANDERBILT (US) 2004-12-01 EP disclosed
US-6284918-B1 ENZYME INHIBITORS VANDERBILT UNIVERSITY 2001-09-04 US disclosed
EP-0958275-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1999-11-24 EP disclosed
US-5973191-A AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE VANDERBILT UNIVERSITY (US) 1999-10-26 US disclosed
WO-1998029382-A1 SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 VANDERBILT UNIVERSITY (US) 1998-07-09 WO disclosed