Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Phenyl Propionic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.70 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenyl Propionic Acid SCHEMBL9385376 | 0.95 | HDAC1 (0.77) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL14715904 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL6672575 | 0.95 | HDAC1 (0.77) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL7736260 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL5351804 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL11668372 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL9175294 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL10878200 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL5351527 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 | |
| Phenyl Propionic Acid SCHEMBL376109 | 0.95 | HDAC1 (0.70) | HDAC1HDAC2HDAC8HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220169603-A1 | NOVEL SALTS, CRYSTALLINE FORMS AND PREMIX OF HYPOLIPIDEMIC AGENT | ZYDUS LIFESCIENCES LIMITED (IN) | 2022-06-02 | — | — | US | disclosed |
| EP-2670486-A1 | TREATMENT FOR LIPODYSTROPHY | Cadila Healthcare Limited (IN) | 2013-12-11 | — | — | EP | disclosed |
| WO-2012104869-A1 | TREATMENT FOR LIPODYSTROPHY | CADILA HEALTHCARE LIMITED (IN) | 2012-08-09 | — | — | WO | disclosed |
| EP-0957919-A4 | ANALGESIC COMPOSITION FOR TREATMENT OF MIGRAINE HEADACHES | MAUSKOP ALEXANDER (US) | 2004-07-28 | — | — | EP | disclosed |
| EP-1436268-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Reddy's Laboratories Ltd. (IN) | 2004-07-14 | — | — | EP | disclosed |
| WO-2003033481-A1 | BENZOXAZINE AND BENZOTHIAZINE DERIVATIVES AND PARMACEUTICAL COMPOSITIONS CONTAINING THEM | DR. REDDY'S LABORATORIES LTD. (IN) | 2003-04-24 | — | — | WO | disclosed |
| EP-0957919-A1 | ANALGESIC COMPOSITION FOR TREATMENT OF MIGRAINE HEADACHES | Mauskop, Alexander (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5914129-A | MAGNESIUM SALT, STIMULANT, EFFERVESCING AGENT AND CARRIERS | MAUSKOP ALEXANDER (US) | 1999-06-22 | — | — | US | disclosed |
| WO-1998003179-A1 | ANALGESIC COMPOSITION FOR TREATMENT OF MIGRAINE HEADACHES | MAUSKOP ALEXANDER (US) | 1998-01-29 | — | — | WO | disclosed |
| US-5538959-A | RAPID ABSORPTION, MAGNESIUM SALT | MAUSKOP ALEXANDER (US) | 1996-07-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220169603-A1 | NOVEL SALTS, CRYSTALLINE FORMS AND PREMIX OF HYPOLIPIDEMIC AGENT | SLC5A1, SLC5A2, GBA3 | HDAC1 1092/4885HDAC2 1190/4885HDAC8 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.