Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.53 |
| ▸ | PPARG | P37231 | 3/20 | 0.45 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535015 | 1.00 | PTGS2 (0.53) | PTGS2PPARGPPARACYSLTR2CYSLTR1 | |
| SCHEMBL6248968 | 0.99 | PTGS2 (0.52) | PTGS2PPARGPPARACYSLTR2CYSLTR1 | |
| SCHEMBL6249980 | 0.95 | PTGS2 (0.52) | PTGS2PPARGPPARA | |
| SCHEMBL6247831 | 0.89 | PTGS2 (0.49) | PTGS2 | |
| SCHEMBL7998103 | 0.87 | PTGS2 (0.52) | PTGS2 | |
| SCHEMBL28836190 | 0.86 | PTGS2 (0.52) | PTGS2PPARGPPARACYSLTR2CYSLTR1 | |
| SCHEMBL8002010 | 0.85 | PTGS2 (0.50) | PTGS2 | |
| SCHEMBL7998140 | 0.84 | PTGS2 (0.51) | PTGS2CYSLTR2CYSLTR1 | |
| SCHEMBL7984458 | 0.84 | PTGS2 (0.50) | PTGS2PPARGPPARACYSLTR2CYSLTR1 | |
| SCHEMBL6248483 | 0.83 | PTGS2 (0.48) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958275-A4 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | UNIV VANDERBILT (US) | 2004-12-01 | — | — | EP | disclosed |
| US-6284918-B1 | ENZYME INHIBITORS | VANDERBILT UNIVERSITY | 2001-09-04 | — | — | US | disclosed |
| EP-0958275-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5973191-A | AN ACETOXYPHENYLALKYL SULFIDE, SALT OR HYDRATE | VANDERBILT UNIVERSITY (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1998029382-A1 | SELECTIVE INHIBITORS OF PROSTAGLANDIN ENDOPEROXIDE SYNTHASE-2 | VANDERBILT UNIVERSITY (US) | 1998-07-09 | — | — | WO | disclosed |