Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CCR5 | P51681 | 2/20 | 0.37 |
| ▸ | CCR8 | P51685 | 2/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | METAP1 | P53582 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4270187 | 0.96 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL7114028 | 0.92 | HDAC8 (0.41) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Iodide SCHEMBL6535009 | 0.92 | HDAC8 (0.41) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| SCHEMBL30800591 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Iodide SCHEMBL28731796 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6535289 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL29713633 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| SCHEMBL29810143 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL6534749 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA | |
| SCHEMBL28383937 | 0.87 | HDAC8 (0.44) | HDAC8HSP90AA1CYP2A6KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994834-A4 | LIGATED PLATINUM GROUP METAL CATALYST COMPLEX AND IMPROVED PROCESS FOR CATALYTICALLY CONVERTING ALKANES TO ESTERS AND DERIVATIVES THEREOF | CATALYTICA INC (US) | 2004-12-29 | — | — | EP | disclosed |
| US-20030120125-A1 | Ligated platinum group metal catalyst complex and improved process for catalytically converting alkanes to esters and derivatives thereof | PERIANA ROY A (US) | 2003-06-26 | — | — | US | disclosed |
| EP-0994834-A1 | LIGATED PLATINUM GROUP METAL CATALYST COMPLEX AND IMPROVED PROCESS FOR CATALYTICALLY CONVERTING ALKANES TO ESTERS AND DERIVATIVES THEREOF | CATALYTICA, INC. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998050333-A1 | LIGATED PLATINUM GROUP METAL CATALYST COMPLEX AND IMPROVED PROCESS FOR CATALYTICALLY CONVERTING ALKANES TO ESTERS AND DERIVATIVES THEREOF | CATALYTICA, INC. (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030120125-A1 | Ligated platinum group metal catalyst complex and improved process for catalytically converting alkanes to esters and derivatives thereof | BID, MDH2, LIG4 | ADRB2 3285/4885HDAC8 4314/4885HSP90AA1 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.