Sugi Predict

Sugi Predict / Targets / MDH2

MDH2

Malate dehydrogenase, mitochondrial · P40926 · MDH2 on Sugi Atlas →

6,277 patent compounds predicted against MDH2, 3,729 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL446031 SCHEMBL446031 0.45 13/20
SCHEMBL1836425 SCHEMBL1836425 0.47 11/20
SCHEMBL338553 SCHEMBL338553 0.47 11/20
SCHEMBL4295580 SCHEMBL4295580 0.80 10/20
SCHEMBL1064180 SCHEMBL1064180 0.49 10/20
SCHEMBL988235 SCHEMBL988235 0.42 10/20
SCHEMBL4291874 SCHEMBL4291874 0.44 9/20
SCHEMBL2108184 SCHEMBL2108184 0.44 9/20
1,4-Butanediol 1,4-Butanediol (SCHEMBL1592411) 0.42 9/20
SCHEMBL338551 SCHEMBL338551 0.40 9/20
SCHEMBL1223543 SCHEMBL1223543 0.54 8/20
SCHEMBL2600376 SCHEMBL2600376 0.46 8/20
SCHEMBL821797 SCHEMBL821797 0.43 7/20
SCHEMBL200171 SCHEMBL200171 0.39 7/20
SCHEMBL3299387 SCHEMBL3299387 0.35 7/20
SCHEMBL3912463 SCHEMBL3912463 0.55 6/20
SCHEMBL3375862 SCHEMBL3375862 0.53 6/20
SCHEMBL411772 SCHEMBL411772 0.44 6/20
SCHEMBL480668 SCHEMBL480668 0.44 6/20
Ethylene Glycol Ethylene Glycol (SCHEMBL1832016) 0.43 6/20

Clinical trials — most relevant to MDH2 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Depakote (Divalproex Sodium) for Children With Temper Dysregulation and Severe Mood Swings PHASE4COMPLETED
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease PHASE3COMPLETED
Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency: PHASE3ACTIVE_NOT_RECRUITING
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
A Study to Evaluate Vitamin B3 Derivative to Treat Mitochondrial Myopathy PHASE2ACTIVE_NOT_RECRUITING
Effect of a Wide Spectrum Nutritional Supplement on Mitochondrial Function in Children With Autism Spectrum Disorder PHASE2COMPLETED
EPI-743 for Metabolism or Mitochondrial Disorders PHASE1/PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)? PHASE1UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases nanRECRUITING
Fatty Acid Oxidation Defects and Insulin Sensitivity nanCOMPLETED
MItochondrial Diabetes LOw Carb- Diet Study nanCOMPLETED
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
Energy Requirements in Mitochondrial Disease nanCOMPLETED
Natural History in Primary Mitochondrial Myopathies nanRECRUITING
Natural History Study of Mitochondrial Myopathy nanRECRUITING
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction nanCOMPLETED
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders nanCOMPLETED
Rhizomelic Chondrodysplasia Punctata Registry nanRECRUITING
Identification of Large-Scale Mutations of POLG Gene by QMPSF in Patients With Mitochondrial DNA Instability. nanUNKNOWN
Clinical Study of Hydroxytyrosol (HT) in Mitochondrial Diseases nanCOMPLETED
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy nanCOMPLETED
Nutritional Assessment in Mitochondrial Cytopathy nanCOMPLETED
The Genetics of Diabetes in Southern California Chinese Americans nanWITHDRAWN

Related proteins — ESM-2 sequence neighbours (a MDH2 binder may also engage these)

ProteinNameSimilarity
Q5NVR2 — 1.000 Q5NVR2 →
P08249 — 1.000 P08249 →
K0J107 — 1.000 K0J107 →
P04636 — 1.000 P04636 →
Q32LG3 — 1.000 Q32LG3 →
P00346 — 1.000 P00346 →
Q4R568 — 1.000 Q4R568 →
P17783 — 1.000 P17783 →
Q9ZP06 — 1.000 Q9ZP06 →
P46487 — 0.999 P46487 →
Q43744 — 0.998 Q43744 →
P83373 — 0.998 P83373 →
O02640 — 0.997 O02640 →
Q9LKA3 — 0.996 Q9LKA3 →
Q9Y7R8 — 0.995 Q9Y7R8 →
P61891 — 0.995 P61891 →
B5YSW2 — 0.995 B5YSW2 →
P61890 — 0.995 P61890 →
B2U1U9 — 0.995 B2U1U9 →
Q0T052 — 0.995 Q0T052 →
P17505 — 0.995 P17505 →
Q0TCN0 — 0.994 Q0TCN0 →
Q47C34 — 0.994 Q47C34 →
A9L340 — 0.994 A9L340 →
Q8Z3E0 — 0.993 Q8Z3E0 →
B7UJW8 — 0.993 B7UJW8 →
A9MNX5 — 0.993 A9MNX5 →
A1AGC9 — 0.993 A1AGC9 →
A8A545 — 0.993 A8A545 →
C4ZSX4 — 0.993 C4ZSX4 →