Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Isoleucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 12/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.36 |
| ▸ | FAP | Q12884 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoleucine SCHEMBL5017800 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL703839 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL28231733 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL1537458 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL1537322 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL138092 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL1537461 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL1537321 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL138093 | 0.97 | DPP4 (0.40) | DPP4NOS2NOS3NOS1DPP8 | |
| Isoleucine SCHEMBL159544 | 0.96 | SLC7A5 (0.39) | DPP4NOS2NOS3NOS1DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1064010-A4 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | CONNECTIVE TISSUE IMAGINEERING (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1064010-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | Mrs, Llc (US) | 2001-01-03 | — | — | EP | claimed |
| WO-1999045941-A1 | PEPTIDE COMPOSITIONS AND FORMULATIONS AND USE OF SAME | MRS, LLC (US) | 1999-09-16 | — | — | WO | claimed |
| EP-3298025-A1 | NEW AMINO ACID SEQUENCES WITH MICROBICIDAL ACTIVITY DERIVED FROM NAJA ATRA CARDIOTOXIN 1 (CTX-1) | Università degli Studi di Parma (IT) | 2018-03-28 | — | — | EP | disclosed |
| WO-2016184855-A1 | NEW AMINO ACID SEQUENCES WITH MICROBICIDAL ACTIVITY DERIVED FROM NAJA ATRA CARDIOTOXIN 1 (CTX-1) | Università degli Studi di Parma (IT) | 2016-11-24 | — | — | WO | disclosed |
| US-6069129-A | COMPOSITION FOR TREATING MAMMALIAN TISSUE COMPRISING PEPTIDE(S) OF GIVEN SEQUENCES; APPLYING TO HUMAN SKIN IN A COSMETIC OR THERAPEUTIC FORMULATION RESULTING IN ENHANCED ELASTICITY OF THE SKIN | MRS, LLC (US) | 2000-05-30 | — | — | US | disclosed |