Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MPO | P05164 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.48 |
| ▸ | MIF | P14174 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6535879 | 1.00 | MEN1 (0.58) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL1401159 | 0.88 | KDM4E (0.71) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL7775133 | 0.88 | KDM4E (0.71) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL29233343 | 0.86 | MAPT (0.61) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL27582874 | 0.86 | MEN1 (0.61) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL597229 | 0.83 | KMT2A (0.71) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL6032937 | 0.83 | KMT2A (0.71) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL29136582 | 0.83 | MAPT (0.60) | MEN1KMT2AMAPTKDM4ELMNA | |
| SCHEMBL5970060 | 0.82 | FAAH (0.61) | MEN1KMT2AMAPTKDM4ELMNA | |
| Phenylalanine SCHEMBL10381280 | 0.82 | KMT2A (0.70) | MEN1KMT2AMAPTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228037-A4 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | PICOWER INST MED RES (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1228037-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001032606-A1 | COMPOUNDS HAVING MIF ANTAGONIST ACTIVITY | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 2001-05-10 | — | — | WO | disclosed |