SCHEMBL6535562

SCHEMBL6535562

O=C1Nc2ccc(S(=O)(=O)N3CCCCCC3)cc2C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
CASP3 P42574 4/20 1.00
CASP1 P29466 1/20 0.97
CASP7 P55210 1/20 0.97
CASP9 P55211 1/20 0.97
GAA P10253 1/20 0.62
CA12 O43570 1/20 0.58
CA1 P00915 1/20 0.58
CA2 P00918 1/20 0.58
CA9 Q16790 1/20 0.58
USP2 O75604 1/20 0.56
BRD4 O60885 1/20 0.56
EGFR P00533 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31175908 1.00 CASP3 (1.00) CASP3CASP1CASP7CASP9GAA
SCHEMBL2486952 0.98 CASP3 (1.00) CASP3CASP1CASP7CASP9GAA
SCHEMBL31395806 0.98 CASP3 (1.00) CASP3CASP1CASP7CASP9GAA
SCHEMBL6535690 0.97 CASP3 (1.00) CASP3CASP1CASP7CASP9GAA
SCHEMBL30555459 0.88 CASP3 (0.81) CASP3CASP1CASP7CASP9CA12
SCHEMBL29059079 0.88 CASP3 (0.81) CASP3CASP1CASP7CASP9CA12
SCHEMBL6535504 0.87 CASP3 (0.79) CASP3CASP1CASP7CASP9EGFR
SCHEMBL5988598 0.87 CASP3 (0.79) CASP3CASP1CASP7CASP9CA12
SCHEMBL6535582 0.85 CASP3 (0.75) CASP3CASP1CASP7CASP9
SCHEMBL8307257 0.85 CASP3 (0.75) CASP3CASP1CASP7CASP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403792-B1 INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS SMITHKLINE BEECHAM CORPORATION 2002-06-11 US claimed
EP-1242081-A4 CASPASES AND APOPTOSIS SMITHKLINE BEECHAM CORP (US) 2004-07-21 EP disclosed
EP-1242081-A1 CASPASES AND APOPTOSIS SmithKline Beecham Corporation (US) 2002-09-25 EP disclosed
US-6403792-B1 INHIBIT PRODUCTION OF CASPASE 3 AND 7 IN MAMMALS SMITHKLINE BEECHAM CORPORATION 2002-06-11 US disclosed
WO-2001022966-A1 CASPASES AND APOPTOSIS SMITHKLINE BEECHAM CORPORATION (US) 2001-04-05 WO disclosed