Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GPR3 | P46089 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 11/20 | 0.50 |
| ▸ | PLAU | P00749 | 7/20 | 0.50 |
| ▸ | PLG | P00747 | 6/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 6/20 | 0.50 |
| ▸ | KLK1 | P06870 | 3/20 | 0.50 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.50 |
| ▸ | PLAT | P00750 | 3/20 | 0.45 |
| ▸ | F10 | P00742 | 4/20 | 0.43 |
| ▸ | F7 | P08709 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6536176 | 0.88 | KDM4E (0.53) | KDM4EGPR3F2PLAUPLG | |
| SCHEMBL28327537 | 0.79 | KDM4E (0.55) | KDM4EGPR3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL19264891 | 0.76 | KDM4E (0.64) | KDM4EGPR3F2NPC1LMNA | |
| SCHEMBL4766216 | 0.75 | KDM4E (0.62) | KDM4EGPR3MAPTCYP3A4 | |
| SCHEMBL28988470 | 0.75 | ALOX15 (0.54) | KDM4EGPR3NPC1MAPTRAB9A | |
| Phenanthridine SCHEMBL19747329 | 0.74 | KDM4E (0.67) | KDM4EGPR3PLAUPLGNPC1 | |
| SCHEMBL27676053 | 0.73 | KDM4E (0.60) | KDM4EGPR3MAPTCYP3A4 | |
| SCHEMBL2680789 | 0.73 | KDM4E (0.71) | KDM4EGPR3NPC1LMNAMAPT | |
| SCHEMBL5674933 | 0.71 | MGAM (0.61) | F2PLAUPLGPRSS1KLK1 | |
| SCHEMBL22333732 | 0.71 | KDM4E (0.62) | KDM4EGPR3NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1425015-A4 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL MYERS SQUIBB CO (US) | 2004-12-15 | — | — | EP | claimed |
| EP-1425015-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-09 | — | — | EP | claimed |
| WO-2003015715-A2 | TETRAHYDROQUINOLINE DERIVATIVES AS ANTITHROMBOTIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2003-02-27 | — | — | WO | claimed |