Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 5/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL26137 | 0.88 | — | — | |
| Bicarbonate SCHEMBL1330785 | 0.88 | — | — | |
| Bicarbonate SCHEMBL564381 | 0.88 | CA4 (0.50) | CA4CA1FAHD1LMNAMEN1 | |
| Bicarbonate SCHEMBL30477205 | 0.84 | — | — | |
| Bicarbonate SCHEMBL6322879 | 0.82 | — | — | |
| Bicarbonate SCHEMBL18280949 | 0.82 | — | — | |
| Bicarbonate SCHEMBL1004629 | 0.82 | CA4 (0.46) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL5982221 | 0.82 | — | — | |
| Bicarbonate SCHEMBL1020517 | 0.82 | CA4 (0.46) | CA4CA1FAHD1FFAR3HDAC3 | |
| Bicarbonate SCHEMBL14562512 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6803147-B2 | MIXING SILVER-CONTAINING COMPOUND WITH A VANADIUM-CONTAINING COMPOUND TO FORM A REACTION MIXTURE; HEATING THE REACTION MIXTURE IN A REDUCED OXYGEN ATMOSPHERE TO PRODUCE THE CATHODE ACTIVE MATERIAL | WILSON GREATBATCH TECHNOLOGIES, INC. | 2004-10-12 | — | — | US | disclosed |
| US-20020086209-A1 | Mixing silver-containing compound with a vanadium-containing compound to form a reaction mixture; heating the reaction mixture in a reduced oxygen atmosphere to produce the cathode active material | GREATBATCH LTD. | 2002-07-04 | — | — | US | disclosed |
| EP-1220342-A2 | Silver vanadium oxide having low internal resistance and method of manufacture | WILSON GREATBATCH LTD. (US) | 2002-07-03 | — | — | EP | disclosed |