Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 17/20 | 1.00 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595762 | 0.78 | ELANE (0.64) | ELANEPARP1 | |
| SCHEMBL289180 | 0.72 | ELANE (0.56) | ELANEPARP1 | |
| SCHEMBL282843 | 0.70 | ELANE (1.00) | ELANECTRB1 | |
| SCHEMBL6447861 | 0.70 | ELANE (0.54) | ELANEPARP1 | |
| SCHEMBL7182976 | 0.69 | ELANE (0.53) | ELANECTRB1 | |
| SCHEMBL29698724 | 0.68 | ELANE (0.52) | ELANEPARP1 | |
| SCHEMBL912750 | 0.68 | ELANE (0.52) | ELANEPARP1 | |
| SCHEMBL8543622 | 0.68 | ELANE (0.70) | ELANECTRB1 | |
| SCHEMBL8404515 | 0.67 | ELANE (0.50) | ELANEPARP1 | |
| SCHEMBL8016730 | 0.67 | ELANE (0.76) | ELANECTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040229312-A1 | Engineered human kunitz-type protease inhibitor | GENEPROT, INC. (CH) | 2004-11-18 | — | — | US | disclosed |
| EP-1399560-A2 | ENGINEERED HUMAN KUNITZ-TYPE PROTEASE INHIBITOR | Geneprot, Inc. (CH) | 2004-03-24 | — | — | EP | disclosed |
| US-6689582-B1 | EXPRESSION VECTOR; HOST CELLS; NOVEL HUMAN SERINE PROTEINASE INHIBITOR OF THE KUNITZ FAMILY THAT EXHIBITS GREATER POTENCY TOWARDS NEUTRAL SERINE PROTEINASES THAN TRYPSIN-LIKE PROTEINASES; FOR VARIOUS INFLAMMATORY DISEASES | BAYER PHARMACEUTICALS CORPORATION | 2004-02-10 | — | — | US | disclosed |
| WO-2003070770-A2 | ENGINEERED HUMAN KUNITZ-TYPE PROTEASE INHIBITOR | GENEPROT, INC. (CH) | 2003-08-28 | — | — | WO | disclosed |
| US-6294648-B1 | A MUTANT PROTEIN OF THE KUNITZ FAMILY; THERAPY FOR EMPHYSEMA, PULMANARY FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, CYSTIC FIBROSIS, RHEUMATOID ARTHRITIS, ORGAN FAILURE AND GLOMERULONEPHRITIS | BAYER CORPORATION | 2001-09-25 | — | — | US | disclosed |
| US-6180607-B1 | EMPLOYED AS THERAPEUTICS IN DISEASES SUCH AS EMPHYSEMA, IDIOPATHIC PULMONARY FIBROSIS, ADULT RESPIRATORY DISTRESS SYNDROME, CYSTIC FIBROSIS, RHEUMATOID ARTHRITIS, ORGAN FAILURE, AND GLOMERULONEPHRITIS | SILICON VALLEY BANK | 2001-01-30 | — | — | US | disclosed |