Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.46 |
| ▸ | JAK2 | O60674 | 12/20 | 0.46 |
| ▸ | JAK1 | P23458 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537512 | 0.89 | TYK2 (0.48) | TYK2JAK2JAK1MAPTTP53 | |
| SCHEMBL6538173 | 0.86 | TYK2 (0.48) | TYK2JAK2JAK1MAPTTP53 | |
| SCHEMBL6537731 | 0.86 | TYK2 (0.47) | TYK2JAK2JAK1MAPTTP53 | |
| SCHEMBL6538091 | 0.84 | TYK2 (0.43) | TYK2JAK2JAK1MAPTTP53 | |
| SCHEMBL6538087 | 0.82 | TYK2 (0.51) | TYK2JAK2JAK1MAPTCYP3A4 | |
| SCHEMBL6536340 | 0.81 | TYK2 (0.50) | TYK2JAK2JAK1RAB9ACDK9 | |
| SCHEMBL6537653 | 0.79 | TYK2 (0.47) | TYK2JAK2JAK1MAPTRAB9A | |
| SCHEMBL6537668 | 0.79 | TYK2 (0.55) | TYK2JAK2JAK1MAPTCYP3A4 | |
| SCHEMBL6537684 | 0.79 | CYP3A4 (0.48) | TYK2JAK2JAK1CYP3A4 | |
| SCHEMBL6537972 | 0.78 | TYK2 (0.52) | TYK2JAK2JAK1CYP3A4CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |