Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 4/20 | 0.40 |
| ▸ | TYK2 | P29597 | 4/20 | 0.40 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537836 | 0.91 | TYK2 (0.39) | JAK2JAK1TYK2SLC16A3MEN1 | |
| SCHEMBL6538286 | 0.88 | PTGES (0.41) | JAK2JAK1TYK2SLC16A3MEN1 | |
| SCHEMBL6538001 | 0.87 | TP53 (0.39) | JAK2JAK1TYK2SLC16A3MEN1 | |
| SCHEMBL6538337 | 0.87 | SLC16A3 (0.40) | JAK2JAK1TYK2SLC16A3ITGB1 | |
| SCHEMBL6537916 | 0.86 | TYK2 (0.38) | JAK2JAK1TYK2SLC16A3MEN1 | |
| SCHEMBL6537496 | 0.85 | TYK2 (0.41) | JAK2JAK1TYK2RAB9ALMNA | |
| SCHEMBL6537843 | 0.84 | SLC16A3 (0.42) | JAK2JAK1TYK2SLC16A3ITGB1 | |
| Hydrochloric Acid SCHEMBL6537776 | 0.80 | SLC16A3 (0.39) | JAK2JAK1TYK2SLC16A3ITGB1 | |
| SCHEMBL6537687 | 0.79 | TYK2 (0.43) | JAK2JAK1TYK2SLC16A3NPC1 | |
| SCHEMBL6538125 | 0.79 | SLC16A3 (0.41) | JAK2JAK1TYK2SLC16A3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |