Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 17/20 | 0.49 |
| ▸ | JAK2 | O60674 | 13/20 | 0.49 |
| ▸ | JAK1 | P23458 | 7/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537352 | 0.89 | TYK2 (0.51) | TYK2JAK2JAK1GAAALDH1A1 | |
| SCHEMBL6537529 | 0.88 | TYK2 (0.50) | TYK2JAK2JAK1CDK9JAK3 | |
| SCHEMBL6537598 | 0.87 | PTGES (0.47) | TYK2JAK2JAK1GAAPTGES | |
| SCHEMBL6538207 | 0.86 | TYK2 (0.51) | TYK2JAK2JAK1GAAALDH1A1 | |
| SCHEMBL6537718 | 0.85 | TYK2 (0.50) | TYK2JAK2JAK1PTGESCDK9 | |
| SCHEMBL6538189 | 0.84 | TYK2 (0.51) | TYK2JAK2JAK1PTGESCDK9 | |
| Dimethylamine SCHEMBL8474406 | 0.84 | TYK2 (0.49) | TYK2JAK2JAK1GAAALDH1A1 | |
| SCHEMBL6537364 | 0.82 | TYK2 (0.46) | TYK2JAK2JAK1PTGESALDH1A1 | |
| SCHEMBL6537731 | 0.79 | TYK2 (0.47) | TYK2JAK2JAK1GAAALDH1A1 | |
| SCHEMBL6537865 | 0.78 | TYK2 (0.47) | TYK2JAK2JAK1GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |