Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.34 |
| ▸ | CDK14 | O94921 | 3/20 | 0.34 |
| ▸ | CCNY | Q8ND76 | 3/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.32 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6538030 | 0.84 | JAK2 (0.46) | TYK2JAK2JAK1HDAC1CDK14 | |
| SCHEMBL6538102 | 0.84 | TYK2 (0.46) | TYK2JAK2JAK1PTGESKDR | |
| SCHEMBL6537693 | 0.80 | ALDH1A1 (0.43) | TYK2JAK2JAK1ALDH1A1HPGD | |
| SCHEMBL6537625 | 0.78 | TYK2 (0.52) | TYK2JAK2JAK1HDAC1KDR | |
| SCHEMBL6537372 | 0.77 | TYK2 (0.43) | TYK2JAK2JAK1ALDH1A1HPGD | |
| SCHEMBL6538269 | 0.76 | TYK2 (0.42) | TYK2JAK2JAK1ALDH1A1HDAC1 | |
| SCHEMBL6538044 | 0.74 | TYK2 (0.43) | TYK2JAK2JAK1CDK14CCNY | |
| SCHEMBL6537640 | 0.74 | TYK2 (0.43) | TYK2JAK2JAK1PTGESCYP3A4 | |
| SCHEMBL8587312 | 0.71 | TYK2 (0.44) | TYK2JAK2JAK1HDAC1SLC16A3 | |
| SCHEMBL6538034 | 0.71 | TYK2 (0.45) | TYK2JAK2JAK1HDAC1SLC16A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |