Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 11/20 | 0.51 |
| ▸ | JAK2 | O60674 | 10/20 | 0.51 |
| ▸ | JAK1 | P23458 | 7/20 | 0.51 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CCR1 | P32246 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CCR8 | P51685 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537794 | 0.89 | TYK2 (0.50) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538073 | 0.85 | TYK2 (0.56) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538163 | 0.82 | NR4A2 (0.57) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538084 | 0.82 | TYK2 (0.53) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537989 | 0.82 | TYK2 (0.51) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538161 | 0.81 | TYK2 (0.52) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537668 | 0.81 | TYK2 (0.55) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6538203 | 0.81 | TYK2 (0.55) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537462 | 0.81 | TYK2 (0.49) | TYK2JAK2JAK1KDRCYP3A4 | |
| SCHEMBL6537461 | 0.80 | TYK2 (0.57) | TYK2JAK2JAK1KDRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876345-B1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-08-18 | — | — | EP | disclosed |
| US-6008230-A | TREATING BONE DISEASES CAUSED BY ABNORMAL BONE METABOLISM IN HUMAN BEING OR ANIMALS AS THE INHIBITORS OF BONE RESORPTION OR THE INHIBITORS OF BONE METASTASIS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-12-28 | — | — | US | disclosed |
| EP-0876345-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997014681-A1 | HETEROCYCLIC COMPOUNDS AS H+-ATPASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-04-24 | — | — | WO | disclosed |