Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | AKT2 | P31751 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.38 |
| ▸ | ABL1 | P00519 | 4/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | HCK | P08631 | 4/20 | 0.38 |
| ▸ | SRC | P12931 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.38 |
| ▸ | MTOR | P42345 | 4/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.38 |
| ▸ | PRKDC | P78527 | 4/20 | 0.38 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 5/20 | 0.37 |
| ▸ | KDM6B | O15054 | 1/20 | 0.37 |
| ▸ | KDM5C | P41229 | 1/20 | 0.37 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6537897 | 0.87 | NPSR1 (0.47) | AKT1AKT2KDM5AKDM6BKDM5C | |
| SCHEMBL6539002 | 0.86 | RET (0.37) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL6538477 | 0.85 | ADORA2A (0.38) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL6538844 | 0.85 | TP53 (0.37) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL6538925 | 0.85 | AKT1 (0.42) | AKT1AKT2KDM5AKDM6BKDM5C | |
| SCHEMBL6539038 | 0.84 | ADORA2A (0.36) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL6539119 | 0.84 | ADORA2A (0.36) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL6538926 | 0.84 | POLB (0.39) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL6539015 | 0.82 | KDM5A (0.42) | KDM5AKDM6BKDM5CKDM5DKDM4C | |
| SCHEMBL6538474 | 0.81 | RET (0.41) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067955-A1 | Pyridazinone compound and pharmaceutical use thereof | FUJISAWA PHARMACEUTICAL CO. LTD. (JP) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067955-A1 | Pyridazinone compound and pharmaceutical use thereof | ADORA1, ADORA2A, P2RX5 | AKT1 1821/4885AKT2 2161/4885PIK3CD 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.